Related Experiment Video
Updated: May 21, 2025

Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip
Published on: February 16, 2024
The Role of Endometrial Microbiota in Fertility and Reproductive Health: A Narrative Review
Priti Karadbhajne1, Akash More1, Hellen Y Dzoagbe2
1Clinical Embryology, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Abstract:
This review explores the correlation between endometrial microbes and infertility, focusing on the impact of endometrial microbiota on fertility outcomes. The healthy status of uterine microorganisms, predominantly Lactobacillus, plays a crucial role in reproductive health. Studies have shown that the endometrial microbiota composition changes with hormonal fluctuations during the menstrual cycle, affecting endometrial receptivity and embryo implantation. The presence of specific bacteria, such as Lactobacillus species, has been associated with successful pregnancy outcomes, while dysbiosis in the endometrial microbiota has been linked to implantation failure and infertility. Factors like age, hormonal changes, and immune responses influence the composition of endometrial microbes, impacting fertility. Chronic endometritis, characterized by inflammation of the endometrium, has been linked to recurrent implantation failure and infertility. Understanding the complex interactions between endometrial microbiota, immune responses, and hormonal influences is crucial for improving fertility treatments and outcomes.
Related Concept Videos
Oogenesis
Infertility in Females
Endometriosis, a condition characterized by abnormal growth of...
Fertilization
Bacterial Flora of the Large Intestine
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
Infertility in Males

