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Updated: May 21, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
[Suspected hypersensitivity probably related to the use of morphine: A case report]
Roxana De Las Salas1, Gregorio Díaz-Morales2, Juana Borja-González3
1RD: Enf. Universidad del Norte. M.Sc. Ciencias-Farmacología. Ph.D. Ciencias Farmacéuticas. Profesora Asistente, Departamento de Enfermería, Universidad del Norte. Barranquilla, Colombia. rdelassalas@uninorte.edu.co Universidad del Norte Universidad del Norte Departamento de Enfermería Barranquilla Colombia rdelassalas@uninorte.edu.co.
Abstract:
The case of a 46-year-old male patient is presented. He was admitted to the emergency department with a clinical picture of oppressive chest pain of 10/10 intensity on the pain analog scale, which had been evolving for one hour. After evaluation and based on electrocardiographic and laboratory findings, the patient was diagnosed with acute myocardial infarction with st elevation. Additionally, aortic dissection and hypertensive emergency with end-organ damage to the heart were suspected due to intense precordial pain and blood pressure readings of 230/120 mmHg. As part of the therapeutic approach, 3 mg of intravenous morphine diluted in 10 ml of 0.9 % saline solution were administered. Following administration, the patient exhibited suspected hypersensitivity. Therefore, a suspected adverse event assessment was performed using the Naranjo algorithm, and it was established that the effects of morphine were plausible (category probable).
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