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Review Article--Exercise and Hypertrophic Cardiomyopathy: Risks, Benefits, and Safety - A Systematic Review and
Arif Albulushi1, Qasim Al Abri2, Ahmed Tawfek1
1Department of Adult Cardiology, National Heart Center, The Royal Hospital, Muscat, Oman.
Journal of the Saudi Heart Association
|March 18, 2025
Summary
Tailored exercise programs for hypertrophic cardiomyopathy (HCM) patients show significant benefits. Moderate exercise improves fitness and quality of life without increasing risks, suggesting personalized regimens are safe and effective for managing HCM.
Area of Science:
- Cardiology
- Exercise Physiology
- Clinical Research
Background:
- Hypertrophic cardiomyopathy (HCM) traditionally involves conservative exercise advice due to sudden cardiac death (SCD) risks.
- Emerging evidence suggests personalized exercise programs may benefit HCM patients.
- The safety and efficacy of structured, individualized exercise for HCM require thorough evaluation.
Purpose of the Study:
- To systematically review and meta-analyze the impact of various exercise types and intensities on HCM patient outcomes.
- To assess exercise's role in preventing disease progression and arrhythmias in HCM.
- To determine the safety and efficacy of tailored exercise programs for HCM.
Main Methods:
- Comprehensive literature search across PubMed, Embase, Cochrane Library, and cardiology journals.
- Inclusion of studies evaluating exercise interventions in HCM patients with reported clinical outcomes, quality of life, and safety data.
- Data extraction and meta-analysis to quantify the overall impact of exercise on HCM.
Main Results:
- Moderate-intensity exercise significantly improved VO2 max by 3.5 mL/kg/min and reduced NYHA class by -0.5.
- Quality of life measures (physical, emotional, social) showed significant enhancement (SMD +0.40).
- No significant increase in arrhythmias (RR 0.95) or mortality (RR 0.85) was observed.
Conclusions:
- Tailored exercise programs demonstrate potential in managing HCM symptoms and preventing disease progression.
- Personalized exercise regimens offer significant benefits for HCM patients.
- Further research is needed to establish standardized protocols for optimal safety and efficacy in HCM exercise management.
Keywords:
Exercise capacityExercise recommendationsHypertrophic cardiomyopathy (HCM)Quality of lifeSafety and efficacySudden cardiac death (SCD)More Related Videos
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