Related Experiment Video For Xinjiang
Updated: May 8, 2025
Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Human Papillomavirus Prevalence and Genotype Distribution Among Women With Cervical Cytological Abnormalities in
Jing Ma1, Min Yang1, Guohong Huang1
1Clinical Laboratory Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
Objective:
To investigate the genotype distribution and viral loads of human papillomavirus (HPV) among women with cervical cytological abnormalities in Urumqi, Xinjiang, China.
Methods:
The HPV genotyping and viral loads were detected in 9351 patients who underwent the ThinPrep cytology test (TCT) using quantitative real-time polymerase chain reaction.
Result:
The overall HPV infection rate was 21.63%, with a predominance of single and high-risk HPV (hrHPV) infection. The ethnic stratification showed that the infection rates were 17.01% (265/1558) in Uyghur, 21.76% (84/386) in Kazakh, 22.20% (103/464) in Hui, and 22.79% (1490/6539) in Han. The major hrHPV genotype was HPV53 in Kazakh and HPV16 in Uyghur, Han, and Hui ethnic groups. The age-stratified data suggested that the highest HPV infection rate in Han, Hui, and Kazakh women was among 25-34 year-olds, but in the 35-44 year-old group for Uyghur. The infection rates of HPV16 in cervicitis, ASCUS, LSIL, and HSIL groups were significantly different among the five ethnic groups; the viral load of HPV16 showed a positive correlation with the severity of cervical lesions.
Conclusion:
Variations exist in HPV infection and age distribution among different ethnic groups in Xinjiang, while the HPV16 viral load can guide risk stratification of cervical lesion progression.
Related Concept Videos
00:36Viral Mutations
00:57Viral Recombination