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Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Related Experiment Video

Updated: May 21, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

Advances in Spatial Omics Technologies.

Tianxiao Hui¹, Jian Zhou², Muchen Yao³

¹State Key Laboratory of Gene Function and Modulation Research, College of Future Technology, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China.

|March 18, 2025

Summary

This summary is machine-generated.

Spatial omics technologies offer novel ways to study cell types and their functions within tissues. These advanced methods reveal intricate relationships between tissue structure and function, aiding development and disease research.

Keywords:

cancer biology developmental biology neurobiology spatial omics spatial transcriptomics

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Area of Science:

Biotechnology
Genomics
Cell Biology

Background:

Traditional methods lack spatial context in biological samples.
Understanding cellular interactions in tissues is crucial for biological insights.

Purpose of the Study:

To review advancements and strategies in spatial omics technologies.
To summarize applications of spatial omics in biomedical research.
To highlight the impact of spatial omics on life sciences.

Main Methods:

Review of current spatial omics technologies.
Analysis of published research utilizing spatial omics.
Synthesis of findings across various biological domains.

Main Results:

Spatial omics enables detailed analysis of cell types and functions.
These technologies dissect relationships between tissue structure and function.
Applications span nervous system, organ development, and tumor microenvironment.

Conclusions:

Spatial omics technologies are revolutionizing biological research.
They provide unprecedented perspectives on development and disease.
Further advancements will deepen our understanding of life sciences.