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LINC02154 Promotes Esophageal Squamous Cell Carcinoma Progression via the PI3K-AKT-mTOR Signaling Pathway by Interacting With IGF2BP2

  • 0Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Molecular Carcinogenesis +

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March 18, 2025

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March 18, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Long noncoding RNA LINC02154 promotes esophageal squamous cell carcinoma (ESCC) progression by activating the IGF2BP2-PI3K-AKT-mTOR pathway. This lncRNA is a potential diagnostic marker and therapeutic target for ESCC.

Area Of Science

  • Molecular Biology
  • Oncology
  • RNA Biology

Background

  • Long noncoding RNAs (lncRNAs) are implicated in various cancers.
  • The specific role and mechanisms of LINC02154 in esophageal squamous cell carcinoma (ESCC) are not fully understood.

Purpose Of The Study

  • To investigate the role of LINC02154 in ESCC progression.
  • To elucidate the underlying molecular mechanisms.
  • To evaluate LINC02154 as a potential diagnostic marker and therapeutic target for ESCC.

Main Methods

  • Quantitative analysis of LINC02154 expression in ESCC cell lines and tissues.
  • In vitro and in vivo experiments to assess the effects of LINC02154 knockdown on ESCC cell proliferation and migration.
  • Investigation of the interaction between LINC02154 and IGF2BP2.
  • Analysis of the PI3K-AKT-mTOR signaling pathway activation.

Main Results

  • LINC02154 was significantly upregulated in ESCC.
  • LINC02154 knockdown inhibited ESCC cell proliferation and migration in vitro and suppressed tumor progression in vivo.
  • LINC02154 binds to IGF2BP2 and activates the PI3K-AKT-mTOR pathway.
  • High LINC02154 expression correlated with poor prognosis in ESCC patients.

Conclusions

  • LINC02154 acts as an oncogenic factor promoting ESCC progression via the IGF2BP2-PI3K-AKT-mTOR pathway.
  • LINC02154 shows potential as a diagnostic marker and therapeutic target for ESCC.

Keywords:

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