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Feasibility and Reliability of a Monitoring App for Chronic Inflammatory Neuropathies
Doreen L Lemmen1, Ruben P A van Eijk1,2, Jordi W J van Unnik1
1Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.
Journal of the Peripheral Nervous System : JPNS
|March 18, 2025
Summary
Tele-neuromonitoring using an app is feasible and reliable for patients with multifocal motor neuropathy (MMN) and chronic inflammatory demyelinating polyneuropathy (CIDP). High adherence and positive user experience support its use in clinical decision-making.
Area of Science:
- Neurology
- Digital Health
- Clinical Monitoring
Background:
- Multifocal motor neuropathy (MMN) and chronic inflammatory demyelinating polyneuropathy (CIDP) are immune-mediated neuropathies causing muscle weakness and sensory deficits.
- Monitoring treatment response, relapse, and stability in these chronic conditions presents challenges.
- A novel monitoring app was explored to address these monitoring difficulties.
Purpose of the Study:
- To evaluate the feasibility and reliability of a tele-neuromonitoring app for MMN and CIDP patients.
- To assess user experience, adherence, and the accuracy of remote measurements.
- To analyze longitudinal changes in patient-reported outcomes and physical measures.
Main Methods:
- Weekly or monthly monitoring via grip strength, modified timed-up-and go (mTUG), and patient-reported outcome measures (PROMs).
- User experience assessed via questionnaire (0-10 scale); adherence measured as completed assessments.
- Reliability analyzed using intra-class correlation coefficients (ICCs) and standard errors of the mean (SEM); longitudinal changes analyzed with linear mixed-effects models.
Main Results:
- 38 patients with a mean follow-up of 11 months showed high adherence (93%) and positive user experience (8.35/10).
- Remote measurements for grip strength and mTUG demonstrated high reliability (ICCs of 0.96).
- Grip strength significantly increased by 3.1 pounds per 6 months (p=0.016), while mTUG showed no significant change.
Conclusions:
- Tele-neuromonitoring is a feasible and reliable tool for MMN and CIDP patients, evidenced by high adherence, user satisfaction, and strong reliability metrics.
- The app complements routine follow-up care.
- Tele-neuromonitoring facilitates better-informed clinical treatment decisions for immune-mediated neuropathies.
