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Updated: May 21, 2025

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One-pot synthesis of diaroyl benzothiepine-1,1-dioxides
Meng-Yang Chang1,2,3, Nai-Chen Hsueh1
1Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan. mychang@kmu.edu.tw.
Abstract:
We report the one-pot two-step synthesis of diaroyl benzothiepine-1,1-dioxides via rongalite-mediated double sulfination of α-bromoacetophenones followed by double condensation of the resulting 1,3-diaroyl sulfones and o-phthalaldehydes. In the (1C + 1C + 1S + 4C) reaction process, a seven-membered ring system could be constructed by two carbon-sulfur (C-S) single bonds and two carbon-carbon double bonds (CC) under mild conditions. A related putative mechanism is proposed and discussed in this article.
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