Related Experiment Video
Updated: Jan 26, 2026

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
Published on: May 17, 2024
Malignant neoplasms in registered cases of primary immunodeficiency syndrome
Abstract:
The occurrence of malignant neoplasms among registered cases of primary immunodeficiency syndrome was studied. A total of 17 malignant tumors occurred in 596 (2.9%) infant patients; two in eight (25%) patients with Chediak-Higashi syndrome, seven in 49 (14.3%) with ataxia-telangiectasia and one in 12 (8.3%) patients with immunodeficiency with hyper-immunoglobulin-M-emia. The overall incidence of malignant tumors in these cases was 200-300 times that in the general population. The incidence in Japan was compared with that in the U.S.A. and in Italy.
Related Concept Videos
Nephrotic Syndrome I : Introduction
Acute Coronary Syndrome I: Introduction
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Primary Active Transport
Restless Leg Syndrome and Night Terrors
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...

