Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Depression and monoamine oxidase.

H Coper1, E Fähndrich, A Gebert

  • 1Institute of Neuropsychopharmacology, University of Erlangen-Nuremberg.

Progress in Neuro-Psychopharmacology
|January 1, 1979
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Non-Response to Antidepressants: Risk Factors and Therapeutic Possibilities.

Pharmacopsychiatry·2026
Same author

Letter of response to Nabi Z, Stansfeld J, Plöderl M, Wood L, Moncrieff J. Effects of lithium on suicide and suicidal behaviour: a systematic review and meta-analysis of randomised trials. <i>Epidemiol Psychiatr Sci</i>. 2022 Sep 16;31:e65. doi: 10.1017/S204579602200049X.

Epidemiology and psychiatric sciences·2022
Same author

Effect of silicon content on the microstructure evolution, mechanical properties, and biocompatibility of β-type TiNbZrTa alloys fabricated by laser powder bed fusion.

Biomaterials advances·2022
Same author

[Stopping antidepressants: withdrawal symptoms and rebound effects : Review and practical recommendations].

Der Nervenarzt·2022
Same author

Prediction of lithium response using clinical data.

Acta psychiatrica Scandinavica·2019
Same author

[Paresthesia and swollen condition of the tongue].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2017
Same journal

Examination of the effects of pimozide on two conditional discrimination problems differing in levels of task complexity.

Progress in neuro-psychopharmacology·1981
Same journal

An investigation of the interaction between the reinforcing properties of food and ethanol using the place preference paradigm.

Progress in neuro-psychopharmacology·1981
Same journal

Prolactin levels and amphetamine-induced behavioural changes following fluphenazine decanoate administration.

Progress in neuro-psychopharmacology·1981
Same journal

The effects of ethanol, acetaldehyde, morphine and naloxone on histamine methyltransferase activity.

Progress in neuro-psychopharmacology·1981
Same journal

Interactions of trace amines with dopamine in rat striatum.

Progress in neuro-psychopharmacology·1981
Same journal

Screening for amines of psychiatric interest in urine using gas chromatography with electron-capture detection.

Progress in neuro-psychopharmacology·1981
See all related articles

This study investigated monoamine oxidase (MAO) activity in depression using novel methods. Results indicate no significant differences in MAO characteristics between depressed patients and healthy individuals, challenging previous assumptions.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Psychiatry

Background:

  • Previous research on monoamine oxidase (MAO) activity in depression yielded inconsistent results due to methodological variations.
  • Deficiencies in prior studies hindered definitive conclusions regarding the link between MAO activity and depression.

Purpose of the Study:

  • To critically review the relationship between depression and MAO.
  • To investigate MAO activity in depression using refined methodologies and a well-defined patient cohort.

Main Methods:

  • A cohort of 35 psychiatric patients (depressive, manic) and 25 healthy controls were studied.
  • Platelet MAO kinetics (Km, Vmax) and inhibition (IC50) were determined using three substrates (tyramine, tryptamine, phenylethylamine).
  • New methodology involved varied substrate concentrations for more robust kinetic analysis.

Related Experiment Videos

Main Results:

  • Significant correlations were found for Vmax values across all three substrates.
  • Km and IC50 values showed substrate-specific variations.
  • No significant differences in platelet MAO characteristics were observed between patients and controls.
  • Tricyclic antidepressant treatment did not alter MAO activity.

Conclusions:

  • The study found no alterations in platelet MAO characteristics in patients with depression or mania compared to healthy subjects.
  • Findings suggest that MAO activity in platelets may not be a reliable biomarker for depression.
  • Methodological advancements were crucial for obtaining reliable MAO kinetic data.