Core Outcome Set and Reporting Checklist for Studies on Vasa Previa

Area of Science:

• Obstetrics and Gynecology
• Perinatal Medicine
• Clinical Research Methodology

Background:

• Vasa previa is a rare obstetric condition with high fetal and neonatal mortality.
• Standardized outcome reporting is crucial for improving evidence synthesis and clinical practice.

Purpose of the Study:

• To develop a core outcome set for vasa previa research, encompassing screening, diagnosis, and management.
• To establish a reporting checklist to enhance data quality and consistency in vasa previa studies.

Main Methods:

• A 2-round international Delphi survey involving 204 health care professionals and users.
• Virtual consensus meetings and small group discussions were conducted.
• Outcomes were identified through systematic review and qualitative interviews.

Main Results:

• 13 core outcomes were identified, including pregnancy outcomes, neonatal morbidity, and maternal outcomes.
• A 22-item reporting checklist was developed for vasa previa studies.
• The study involved 204 participants from 27 countries.

Conclusions:

• The developed core outcome set and checklist will standardize vasa previa research.
• This initiative is expected to improve data harmonization and evidence synthesis.
• The goal is to enhance clinical practice guidelines and reduce fetal and maternal morbidity/mortality.