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Synergy of Microfluidics and Nanomaterials: A Revolutionary Approach for Cancer Management
Pramoda G1, Mansi Singh1, Piyush Kumar Gupta2,3
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Raebareli, Lucknow, Uttar Pradesh 226002, India.
Abstract:
Cancer affects millions of individuals every year and is the second most common cause of death. Various therapeutic strategies are explored for the management of cancer including radiation therapy and chemotherapy with or without surgical procedures. However, the drawbacks like poor cancer cell targeting and higher toxicity for healthy cells need the advancement of the therapeutic strategy. The exploration of nanomedicine achieves targeted distribution, and the adoption of microfluidics technology for the preparation of the nanoparticulate system has enhanced the efficacy and uniformity of the nanocarriers. The overview of the existing designs of the microfluidics device assisted in the preparation of the nanoparticles, and various nanodelivery systems formulated using the microfluidic device including liposomes, lipidic nanocarriers, quantum dots, polymeric nanoparticles, and metallic nanocarriers are discussed in this review. Further, the challenges associated with the fabrication of the microfluidics device and the fabrication of microfluidics device-based nanoparticles are detailed here.
Insights
Microfluidics technology enhances nanoparticle preparation for targeted cancer nanomedicine delivery. This review details microfluidic devices and various nanocarriers, addressing fabrication challenges for improved cancer therapy.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Cancer remains a leading cause of death, with current therapies like chemotherapy and radiation lacking precise cancer cell targeting and causing significant toxicity to healthy tissues.
- Advancements in nanomedicine offer potential for targeted drug delivery, but efficient and uniform nanocarrier preparation is crucial for therapeutic efficacy.
- Microfluidics technology presents a promising approach for the controlled and scalable synthesis of nanocarriers.
Purpose of the Study:
- To provide a comprehensive overview of microfluidics-assisted nanoparticle fabrication for cancer nanomedicine.
- To discuss various nanodelivery systems prepared using microfluidic devices.
- To highlight the challenges in microfluidic device and nanoparticle fabrication.
Main Methods:
- Review of existing microfluidic device designs for nanoparticle preparation.
- Analysis of different nanodelivery systems formulated via microfluidics, including liposomes, lipidic nanocarriers, quantum dots, polymeric nanoparticles, and metallic nanocarriers.
- Discussion of fabrication challenges for both microfluidic devices and the resulting nanoparticles.
Main Results:
- Microfluidics enables enhanced efficacy and uniformity in nanocarrier preparation compared to traditional methods.
- Diverse nanocarrier types, such as liposomes and polymeric nanoparticles, can be effectively produced using microfluidic platforms.
- Key challenges in microfluidic device fabrication and the subsequent nanoparticle synthesis have been identified.
Conclusions:
- Microfluidics technology is a powerful tool for developing advanced nanomedicine platforms for targeted cancer therapy.
- The precise control offered by microfluidics leads to superior nanocarrier characteristics, improving drug delivery and therapeutic outcomes.
- Addressing fabrication challenges is essential for the widespread clinical translation of microfluidics-based nanomedicine for cancer treatment.
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