Weight-Adjusted Waist Index May Predict Hypertension Plus Hyperuricemia

Area of Science:

• Metabolic Health
• Cardiovascular Disease Risk Factors
• Biomarker Research

Background:

• The weight-adjusted waist index (WWI) is a novel anthropometric measure for estimating body composition.
• Hypertension plus hyperuricemia (HTN-HUA) represents a significant comorbidity with potential cardiovascular implications.

Purpose of the Study:

• To investigate the association between WWI and the prevalence of HTN-HUA.
• To explore the relationship of WWI with hypertension (HTN) and hyperuricemia (HUA) individually.
• To assess the predictive capability of WWI for HTN-HUA.

Main Methods:

• Analysis of data from the National Health and Nutrition Examination Survey (NHANES) database (1999-2018).
• Logistic regression and restricted cubic spline (RCS) analyses to examine associations and nonlinearity.
• Receiver operating characteristic (ROC) curve analysis to evaluate predictive performance.

Main Results:

• A significant positive association was observed between WWI and HTN-HUA, HTN alone, and HUA alone, even after adjusting for confounders.
• The highest WWI quartiles showed substantially increased odds for HTN-HUA (OR 2.13), HTN (OR 1.28), and HUA (OR 1.6) compared to the lowest.
• RCS analysis confirmed a nonlinear relationship between WWI and HTN-HUA, with moderate predictive ability (AUC 0.804).

Conclusions:

• WWI is significantly associated with HTN-HUA, suggesting its utility as a potential screening tool.
• The association between WWI and HTN-HUA is nonlinear and more pronounced in younger, normal-weight individuals.
• WWI may facilitate early detection and management of HTN-HUA.