Related Experiment Video

Updated: May 21, 2025

Creation and Maintenance of a Living Biobank - How We Do It
13:08

Creation and Maintenance of a Living Biobank - How We Do It

Published on: April 10, 2021

7.3K

Use of the BIOGROUP® French laboratories database to conduct CKD observational studies: a pilot EPI-CKD1 study

Claire Visseaux1, Guillaume Pénaranda2, Cécile Conte3

  • 1BPO-BIOEPINE, BIOGROUP, Levallois-Perret, France.

Clinical Chemistry and Laboratory Medicine
|March 18, 2025
PubMed

Insights

This study found that 11.5% of adults had altered kidney function, with older age, diabetes, and heart failure increasing risk. Biogroup data offers insights into cardio-renal risk in large patient populations.

Area of Science:

  • Medical biology
  • Cardio-reno-metabolic disease research
  • Epidemiology

Background:

  • Medical biology is crucial for diagnosing and monitoring cardio-reno-metabolic diseases.
  • National databases often lack essential biological data for comprehensive patient analysis.
  • The EPI-CKD1 study addresses these gaps using real-world data.

Purpose of the Study:

  • To examine the prevalence and incidence of chronic kidney disease (CKD) in an outpatient setting.
  • To assess the impact of heart failure and diabetes on kidney function.
  • To evaluate the utility of Biogroup laboratory data for large-scale observational studies.

Main Methods:

  • Inclusion of adults (≥18 years) with at least one blood creatinine test between January 2021 and June 2022.
  • Measurement of key biomarkers: serum creatinine, estimated glomerular filtration rate (eGFR), hemoglobin A1c, B-type natriuretic peptide (BNP), NT-Pro BNP, and urinary albumin/creatinine ratio (uACR).

Main Results:

  • Over 4 million adults were analyzed, with 11.5% exhibiting altered kidney function.
  • Prevalence of altered kidney function was 8.06%, with an incidence of 5.10%.
  • Older age, diabetes, and heart failure were significantly associated with an increased risk of reduced eGFR (<60 mL/min/1.73 m²).

Conclusions:

  • Biogroup laboratory data is valuable for large-scale observational studies on cardio-renal risk.
  • The study provides medically relevant insights into patients with cardio-renal risk factors.
  • Future research should focus on data enrichment and long-term follow-up for deeper understanding.
Abstract

Keywords:
chronic kidney diseasecomorbiditiesestimated glomerular filtration ratelaboratory databasereal-life study

More Related Videos

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing09:24

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing

Published on: June 9, 2016

9.0K
Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials10:28

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

8.8K

Related Concept Videos

Pedigree Analysis01:35

Pedigree Analysis

Overview
83.3K
Plant Breeding and Biotechnology01:59

Plant Breeding and Biotechnology

Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
18.7K
Bioremediation00:46

Bioremediation

Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
18.1K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
110
The Central Dogma01:20

The Central Dogma

The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
19.6K