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Updated: May 21, 2025

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
Published on: July 24, 2021
Design, programming, and evaluation of a serious game web application to memorise drug classification and properties
Anne-Laure Clairet1, Eros Albérola2, Florent Grossrieder3
1Pôle Pharmaceutique, CHU Besançon, F-25000 Besançon, France; Université de Franche-Comté, EFS, INSERM, RIGHT (UMR 1098), F-25000 Besançon, France.
Background And Purpose:
The pharmacy curriculum has shifted towards integrated teaching, focusing on specific therapeutic areas. However, pharmaceutical analysis needs a robust and comprehensive knowledge of the drug classification.
Educational Activity And Setting:
Apothiquiz is an open-source web application game using multiple-choice questions and feedback to reinforce drug classification knowledge. The game sustains motivation through competitive duel mode and a safe, anonymous single-player mode. Efficacy and perception were evaluated via tests and questionnaires among pharmacy students.
Findings:
A score increase of around 3 points was observed (95 % confidence interval of [3.8; 2.7] in the third year and of [4.3; 2.8] in the fourth year) between pre- and post-test and a high user satisfaction rate, due to the game's accessibility, playability and effective gamification techniques, including corrective feedback and safe, non-judgmental single mode, was observed. Therefore, Apothiquiz provides a valuable complementary retrieval strategy for pharmacy education.
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