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Updated: May 21, 2025

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
Published on: December 9, 2016
[Radiotherapy in Ewing sarcomas]
Line Claude1, Sylvie Helfre2, Nadège Corradini3
1Centre Léon-Bérard, département de radiothérapie oncologique, 69008 Lyon, France.
Abstract:
Ewing sarcomas are the 2nd cause of malignant bone tumors in children and young adults. After induction chemotherapy, local treatment is essential and most often includes surgery of the primary tumor. Radiotherapy may be necessary as an exclusive local procedure when surgery is not possible, or in an adjuvant situation when the surgical procedure must be completed (incomplete resection or poor histological response in particular). Radiotherapy can also concern metastatic sites, particularly in cases of pulmonary metastases and/or in an oligo-metastatic situation. This article provides a review of current indications for radiotherapy, technical modalities of irradiation (delineation of volumes, recommended doses), and the results of recent studies.
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