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Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Updated: May 21, 2025

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

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Published on: December 9, 2016

[Radiotherapy in Ewing sarcomas].

Line Claude¹, Sylvie Helfre², Nadège Corradini³

¹Centre Léon-Bérard, département de radiothérapie oncologique, 69008 Lyon, France.

Bulletin Du Cancer

|March 18, 2025

Summary

This summary is machine-generated.

Radiotherapy is crucial for treating Ewing sarcomas, the second most common pediatric bone cancer. It

Keywords:

Ewing sarcoma Paediatry Pédiatrie Radiotherapy Radiothérapie Sarcomes d’Ewing

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Area of Science:

Pediatric Oncology
Skeletal Tumors
Radiation Oncology

Context:

Ewing sarcoma is the second leading cause of malignant bone tumors in children and young adults.
Local treatment, often surgery, follows induction chemotherapy for primary tumors.
Radiotherapy plays a role when surgery is not feasible or as an adjuvant therapy.

Purpose:

To review current indications for radiotherapy in Ewing sarcoma management.
To detail technical aspects of irradiation, including volume delineation and dosage.
To present outcomes from recent studies on radiotherapy for Ewing sarcoma.

Summary:

Radiotherapy is indicated for primary Ewing sarcoma when surgery is impossible or as an adjuvant treatment for incomplete resections or poor histological response.
It is also used for metastatic sites, especially pulmonary metastases or in oligometastatic disease.
The review covers indications, technical modalities (volumes, doses), and recent study results.

Impact:

Provides a comprehensive overview of radiotherapy's role in Ewing sarcoma.
Guides clinical decision-making for optimal patient treatment strategies.
Highlights the importance of radiotherapy in improving outcomes for Ewing sarcoma patients.