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Updated: May 5, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Four Undescribed Sesquiterpenes From the Rhizomes of Curcuma wenyujin
Lijia Chen1, Hui Wang1, Hong Wang1
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
Abstract:
A total of 16 sesquiterpenes were isolated from the rhizomes of Curcuma wenyujin, including four undescribed sesquiterpenes, namely wenyujinone J-M (1-4), and 12 known molecules (5-16). The structures of undescribed compounds were elucidated based on spectroscopic and spectrometric data analyses. Among them, wenyujinones J (1) and L (3) possessed undescribed sesquiterpenoid skeletons. In addition, all the isolated compounds were evaluated for their protective effect against hydrogen peroxide (H2O2)-induced injury in human hepatic L02 cells and for agonistic effect on farnesoid X receptors situated with human embryonic kidney 293T cells. As a result, compounds 7 and 9 (25 µM) markedly weakened the oxidative damage induced by H2O2 in L02 cells strengthening the cell viability of 72.28% and 74.14%, respectively. Compounds 1, 4, and 16 had a significant agonistic effect at 25 µM, while compounds 5, 7, 9, and 11-14 possessed moderate to weak agonistic effects at the same concentration.
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