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[Long-term survival following neuroblastoma stage IV--a case report]
Insights
Chemotherapy led to complete regression of stage IV-neuroblastoma, including bone metastases, in a young girl. She remained cancer-free for over six years post-treatment, demonstrating treatment efficacy.
Area of Science:
- Pediatric Oncology
- Medical Oncology
Background:
- Stage IV-neuroblastoma is a rare and aggressive childhood cancer.
- Treatment options for advanced neuroblastoma are limited and often associated with significant toxicity.
Observation:
- A 12-month-old female presented with stage IV-neuroblastoma, characterized by a retroperitoneal primary tumor with bladder infiltration, osseous metastases, orbital involvement, and medullary seeding.
- The patient received exclusively chemotherapeutic treatment.
Findings:
- Complete regression of the primary tumor and all metastases was achieved with chemotherapy.
- Extensive calcifications developed post-treatment, gradually resolving over three years.
- The patient remained disease-free for 6.5 years after diagnosis and 4.5 years after completing therapy.
Implications:
- Chemotherapy can be an effective treatment for stage IV-neuroblastoma, leading to long-term remission.
- The development and resolution of calcifications warrant further investigation.
- This case highlights the potential for durable remission in neuroblastoma patients with extensive metastatic disease.
Abstract:
A 12 1/2 months old girl with stage IV-neuroblastoma presented with a retroperitoneal primary and tumor infiltrations of the urinary bladder. She had multiple osseous metastases, unilateral orbital infiltrations and medullary tumor cell seeds. Treatment was exclusively chemotherapeutic. The primary tumour and the metastases regressed completely. Extensive calcifications resulted, and they slowly disappeared over a period of three years. The girl remains free of tumour 6 1/2 years after diagnosis and initiation of therapy and 4 1/2 years after its completion.