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Related Concept Videos

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Related Experiment Video

Updated: May 12, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
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Towards harmonized holmium-166 SPECT image quality for dosimetry: a multi-center, multi-vendor study.

Lovisa E L Westlund Gotby1, Martina Stella2, Camille D E Van Speybroeck3

  • 1Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands. Lovisa.WestlundGotby@radboudumc.nl.

EJNMMI Physics
|March 19, 2025
PubMed
Summary

Triple-energy window (TEW) scatter correction improves Holmium-166 (166Ho) SPECT imaging accuracy over dual-energy window (DEW) methods. This enhances personalized radioembolization dosimetry by providing more reliable SPECT/CT imaging protocols.

Keywords:
DosimetryDual-energy window scatter correctionHolmium-166Image qualityMonte Carlo-based scatter correctionPhantom studyRadioembolizationSPECT/CTTriple-energy window scatter correction

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Area of Science:

  • Nuclear Medicine
  • Medical Imaging Physics
  • Radiotherapy Dosimetry

Background:

  • Personalized 166Ho-radioembolization requires accurate dosimetry from SPECT/CT imaging.
  • Multi-center studies highlight the need for harmonized 166Ho-SPECT imaging protocols.
  • Evaluating acquisition and reconstruction protocols is crucial for reproducible dosimetry.

Purpose of the Study:

  • To quantitatively evaluate 166Ho-SPECT imaging protocols across multiple scanners and centers.
  • To recommend an optimal imaging protocol for harmonized 166Ho-SPECT dosimetry.
  • To assess the impact of scatter correction methods (TEW vs. DEW) on image quality.

Main Methods:

  • 166Ho-chloride filled phantoms imaged on seven SPECT/CT scanners from two vendors.
  • Acquisition used a 81 keV photopeak window with TEW and DEW scatter correction.
  • Image quality assessed via coefficient of variation (noise), contrast recovery coefficients (CRCs), and contrast-to-noise ratios (CNRs).

Main Results:

  • TEW scatter correction yielded superior uniformity and higher CRCs (mean 0.54) compared to DEW (mean 0.44).
  • DEW scatter correction demonstrated lower noise levels (16% lower on average) than TEW.
  • Vendor-neutral reconstructions revealed hardware-dependent differences in system sensitivity and image characteristics.

Conclusions:

  • TEW scatter correction enhances the accuracy of 166Ho-SPECT imaging compared to DEW.
  • Adoption of TEW scatter correction is recommended for clinical 166Ho-dosimetry workflows.
  • Scanner hardware significantly impacts SPECT/CT image quality, necessitating protocol harmonization.