Multifaceted role of transgelin isoforms in cancer hallmarks
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View abstract on PubMed
Summary
This summary is machine-generated.Transgelins (TAGLNs) are actin-binding proteins implicated in various diseases, including cancer. This review explores their dual role in tumor suppression and progression, highlighting their potential as cancer biomarkers and therapeutic targets.
Area Of Science
- Molecular Biology
- Cell Biology
- Oncology
Background
- Transgelins (TAGLNs) are actin-binding proteins in the calponin family, regulating actin-myosin interactions and cell motility.
- TAGLNs are expressed in various cell types and are implicated in diseases like cancer, pulmonary arterial hypertension, and diabetes.
- TAGLN family comprises three isoforms: TAGLN1, TAGLN2, and TAGLN3.
Purpose Of The Study
- To investigate the role of Transgelins (TAGLNs) as potential cancer biomarkers.
- To explore the dual function of TAGLNs in tumor suppression and oncogenesis across different cancer types.
- To examine the interplay between TAGLN2, microtubule-associated proteins (MTs), and chemoresistance.
Main Methods
- Literature review of studies on Transgelins (TAGLNs) in cancer.
- Analysis of TAGLN expression profiles in various tumor types.
- Investigation of the molecular mechanisms underlying TAGLN involvement in carcinogenesis and chemoresistance.
Main Results
- TAGLNs exhibit tissue-specific roles, acting as tumor suppressors or oncogenes depending on the tumor context.
- TAGLN expression profiles correlate with patient outcomes and can serve as prognostic/diagnostic biomarkers.
- TAGLN2 interacts with MT-2, influencing chemoresistance in cancer cells.
Conclusions
- Transgelins (TAGLNs) represent promising targets for novel cancer therapeutics due to their multifaceted roles.
- Targeting the interplay between TAGLNs and MTs could reverse tumor progression and overcome chemoresistance.
- TAGLNs hold potential as versatile biomarkers for cancer diagnosis and prognosis.
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