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Published on: August 21, 2021
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A multiple-crosslinked injectable hydrogel for modulating tissue microenvironment and accelerating infected diabetic
Zhengduo Zhang1, Yuanyuan Ding2, Huipu Yuan2
1Center for Global Health, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, China.
Journal of Nanobiotechnology
|March 19, 2025
Summary
This study presents a novel hydrogel that accelerates diabetic wound healing by releasing copper and protocatechualdehyde (PA) to combat oxidative stress, inflammation, and bacterial infections. The CuPA complex effectively inhibits Staphylococcus aureus growth, promoting tissue repair.
Area of Science:
- Biomaterials Science
- Wound Healing Research
- Infectious Disease Management
Background:
- Diabetic wound healing is impaired by oxidative stress, inflammation, and bacterial infections.
- Current treatments require advanced dressings to manage complex wound environments.
Purpose of the Study:
- To develop a multiple-crosslinked injectable hydrogel (GCP) for enhanced diabetic wound healing.
- To investigate the therapeutic mechanisms of the hydrogel, including its antibacterial and anti-inflammatory properties.
Main Methods:
- GCP hydrogel synthesized via radical polymerization, copper-polyphenol coordination, and Schiff base bonds.
- Hydrogel degradation in acidic diabetic wound microenvironments releases active components (copper ions and protocatechualdehyde).
- 16S rRNA sequencing used to elucidate the antibacterial mechanism against Staphylococcus aureus.
Main Results:
- The released CuPA complexes scavenge reactive oxygen species (ROS), promote angiogenesis and cell migration.
- Significant acceleration of infected diabetic wound healing observed.
- CuPA complexes inhibit S. aureus by downregulating specific genes, hindering protein synthesis, and enhancing oxidoreductase activity.
Conclusions:
- The GCP hydrogel effectively remodels the tissue microenvironment for accelerated infected diabetic wound healing.
- The study provides insights into the antibacterial mechanisms of CuPA complexes.
- This hydrogel platform offers potential for developing advanced biomedical materials and treating clinical diseases.
