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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Mirvetuximab soravtansine: current and future applications
Beihua Kong1, Wenxin Zheng2,3,4
1Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, China.
Journal of Hematology & Oncology
|March 19, 2025
Summary
Mirvetuximab soravtansine shows promise for treating ovarian epithelial cancer. This antibody-drug conjugate may also prevent precursor lesions from progressing to invasive high-grade serous carcinoma.
Area of Science:
- Gynecologic Oncology
- Precision Medicine
- Drug Development
Background:
- Ovarian epithelial cancer (OEC), especially high-grade serous carcinoma (HGSC), presents significant challenges due to late diagnosis and high recurrence rates.
- Mirvetuximab soravtansine (MIRV), an antibody-drug conjugate targeting folate receptor alpha (FRα), has shown efficacy in platinum-resistant OEC.
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