Related Experiment Video
Updated: May 21, 2025
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
[Amputation risk scale in patients with acute limb ischemia]
N G Khorev1,2, A A Chichvarov1,2, S V Sapelkin3
1Altai State Medical University, Barnaul, Russia.
Objective:
To create a scale for predicting amputation in patients with acute limb ischemia.
Material And Methods:
We retrospectively analyzed inpatient treatment data of 1.353 patients over a 22-year period. Patients were divided into two groups depending on limb salvage (n=1.212) and limb loss (n=141). Six factors influencing the risk of limb amputation were identified, and odds ratio for each factor was assessed.
Results:
A scoring scale including 15 clinical and laboratory parameters was created. Prognostic ability of the scale was assessed using ROC analysis. AUC was 0.794 with 95% CI 0.755-0.833. The median score for group 1 (limb salvage) was 17 [14; 21], for group 2 (amputation) - 23 [19; 26] (p<0.0001). We stratified groups of low (up to 4.2%), medium (4.3-19.2%) and high (19.3-55.7%) risk of limb amputation in patients with acute limb ischemia.
Conclusion:
A simple scale for assessing the probability of limb amputation in patients with acute ischemia was developed. Practical application of this tool is possible in surgical and specialized departments.
