Informing Implementation Strategies for Pharmacogenomics in Cancer: Development of Survey Tools for Healthcare...

Area of Science:

• Pharmacogenomics
• Cancer Care
• Implementation Science

Background:

• Clinical pharmacogenomics (PGx) integration in cancer care is limited.
• Despite evidence and guidelines, routine use of PGx is suboptimal.
• There's a need to understand knowledge and attitudes of stakeholders.

Purpose of the Study:

• Develop survey tools for healthcare professionals (HCPs) and consumers (patients/carers).
• Assess knowledge, attitudes, practices, perceptions, and education needs regarding PGx.
• Inform strategies for implementing PGx in solid and hematologic cancers.

Main Methods:

• A three-phase mixed-methods approach was used for survey development.
• Systematic literature review and the Theoretical Domains Framework informed content.
• Priority partnership meetings and validity/health literacy assessments refined the tools.

Main Results:

• Separate survey tools were created for HCPs and consumers.
• Surveys cover demographics, experience, knowledge, attitudes, practices, perceptions, education, and vignettes.
• High content/face validity and acceptable health literacy (median Flesch Kincaid Grade 6) were achieved for consumer surveys.

Conclusions:

• Validated survey tools are ready for use in cancer care settings.
• Evidence generated will guide local PGx implementation strategies.
• The tools aim to promote broader integration of pharmacogenomics in clinical practice.