Eosinophil percentage and platelet counts: Association with in-hospital mortality in ST-segment elevated myocardial
Mahtab Mashayekhi1, Mahdokht Rezaei1, Abbas Allami1
1Boali Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Insights
Platelet count and eosinophil percentage are significant indicators for ST-segment elevation myocardial infarction (STEMI) prognosis. Higher platelet counts and specific eosinophil levels correlate with in-hospital mortality and ejection fraction in STEMI patients.
Area of Science:
- Cardiology
- Hematology
- Clinical Pathology
Background:
- ST-segment elevation myocardial infarction (STEMI) arises from coronary artery blockages.
- Eosinophils have a complex role in STEMI, influencing thrombus formation and tissue healing.
- Understanding prognostic markers is crucial for managing STEMI patients.
Purpose of the Study:
- To investigate the association between eosinophil percentage and platelet counts with in-hospital prognosis in STEMI patients.
- To determine the predictive value of these markers for mortality and left ventricular ejection fraction (LVEF).
Main Methods:
- A cross-sectional study of 100 STEMI patients (age ≥18) was conducted.
- Data collected included demographic, clinical, and laboratory findings, focusing on eosinophil percentage and platelet counts.
- In-hospital outcomes such as mortality, arrhythmia, and LVEF were recorded and analyzed.
Main Results:
- A significant correlation was observed between eosinophil percentage and mortality (p=0.032).
- Platelet count also showed a significant association with mortality (p=0.008).
- Eosinophil percentage was significantly related to ejection fraction (p<0.001).
Conclusions:
- Platelet count is a significant prognostic indicator for in-hospital outcomes in STEMI, indicating increased mortality risk.
- Eosinophil percentage demonstrates a notable relationship with ejection fraction in STEMI patients.
- These findings highlight potential biomarkers for risk stratification in STEMI management.
Background:
ST-segment elevation myocardial infarction (STEMI) results from coronary artery blockage due to ruptured atherosclerotic plaque. Eosinophils play a dual role in STEMI, contributing to thrombus formation and tissue repair. This study investigates the association between eosinophil percentage, platelet counts, and in-hospital prognosis in STEMI patients.
Methods:
A cross-sectional study was conducted from September 2019 to February 2020, including patients aged 18 and above with a STEMI diagnosis. In-hospital mortality, arrhythmia, and left ventricular ejection fraction (LVEF) were recorded. Demographic data, clinical manifestations, and laboratory investigations were collected. Data were analyzed using SPSS (version 25.0), with a P value of <0.05 considered significant.
Results:
The study included 100 STEMI patients with a mean age of 65±13.26 years; 75% were male. The mortality rate was 13%. A significant relationship was found between eosinophil percentage and mortality (p=0.032), and platelet count also correlated significantly with mortality (p=0.008). The association between eosinophil percentage and EF was significant (p<0.001). The area under the ROC curve was 0.705 (95% CI 0.605 - 0.792) for platelet counts and 0.679 (95% CI 0.577 - 0.770) for eosinophil percentage in differentiating live and expired patients.
Conclusion:
Platelet count could be a significant prognostic indicator for in-hospital outcomes in STEMI patients, suggesting an increased risk of mortality. Additionally, there is a notable relationship between eosinophil percentage and ejection fraction (EF).
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