Related Experiment Video
Updated: May 21, 2025
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
9.2K
Rethinking cardiovascular risk: The emerging role of lipoprotein(a) screening
Victoria Clair1, Francis M Zirille2, Edward Gill2
1School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
American Journal of Preventive Cardiology
|March 19, 2025
Summary
Screening for Lipoprotein(a) [Lp(a)], a key inherited cardiovascular disease risk factor, is crucial. Universal screening and advanced measurement methods can improve early detection and personalized prevention strategies for cardiovascular disease.
Area of Science:
- Cardiology
- Genetics
- Preventive Medicine
Background:
- Lipoprotein(a) [Lp(a)] is a significant, genetically inherited risk factor for cardiovascular disease (CVD).
- Elevated Lp(a) levels increase the risk of myocardial infarction and aortic valve stenosis by 2-3 fold.
- Limited integration of Lp(a) screening into practice is due to measurement inconsistencies and lack of targeted treatments.
Purpose of the Study:
- To clarify the role of Lp(a) in cardiovascular health.
- To examine evidence on optimal screening strategies, including who, when, and how to measure Lp(a).
- To support the integration of Lp(a) screening into routine cardiovascular risk assessment.
Main Methods:
- Review of current evidence on Lp(a) measurement and clinical relevance.
- Analysis of recommendations for screening across different populations.
- Evaluation of advancements in assay technology and emerging therapies.
Main Results:
- Universal, one-time screening for adults is recommended.
- Selective screening is advised for high-risk pediatric patients and those with familial hypercholesterolemia or chronic kidney disease.
- Advances in assay technology enable more precise Lp(a) measurement for improved risk stratification.
Conclusions:
- Lp(a) screening is essential for comprehensive cardiovascular risk assessment.
- Improved screening and emerging therapies can enhance early detection and personalized CVD prevention.
- Integrating Lp(a) assessment can benefit diverse patient populations in managing cardiovascular risk.
Related Concept Videos
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
111
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
111
01:29Cholesterol: Significance and Regulation
483
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
483
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
40
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
40
01:31Lipid-derived Compounds in the Human Body
4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
492
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
492
01:24Overview of Lipid Metabolism
902
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
902