Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

454
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
454
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
Overview of Exosomes01:36

Overview of Exosomes

2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K
Cancer Vaccines01:30

Cancer Vaccines

313
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
313
Metastasis02:30

Metastasis

5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interpretable and causal machine learning unveil novel insights of PFAS effects on aquatic microalgal activity: key driving features, multidimensional interactions, nonlinear microalgal response patterns and species-dependent structural effects.

Journal of hazardous materials·2026
Same author

Multifactor meta-analysis reveals context-dependent inhibitory efficiency and mechanisms of allelochemicals against Microcystis aeruginosa and concurrent microcystin-pollution risk.

Environmental research·2026
Same author

A robust supramolecular ionic elastomer with efficient self-healing and excellent ionic conductivity for strain sensors and human respiration.

Journal of colloid and interface science·2026
Same author

A risk assessment indicator system for common diseases in children and adolescents.

PloS one·2026
Same author

First complete genomic sequencing of recent canine rabies viruses in Sierra Leone suggests cross-border transmission of Africa 2H subclade.

Virologica Sinica·2026
Same author

Advances in Quinazolinone-Based Tumor-Targeted Inhibitors.

Chemistry & biodiversity·2026

Related Experiment Video

Updated: May 21, 2025

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
08:02

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells

Published on: September 23, 2021

2.5K

Tumor-derived extracellular vesicles: key drivers of immunomodulation in breast cancer.

Jieming Li1,2, Shuo Yu3, Min Rao4

  • 1Traditional Chinese Medicine (Zhong Jing) School, Henan University of Chinese Medicine, Zhengzhou, China.

Frontiers in Immunology
|March 19, 2025
PubMed
Summary

Breast cancer (BC) progression is driven by tumor-derived extracellular vesicles (EVs). These EVs regulate the tumor microenvironment, promote immune evasion, and mediate drug resistance, offering potential therapeutic targets.

Keywords:
T cellsbreast cancerextracellular vesiclesimmune regulationmacrophages

More Related Videos

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

10.1K
Evaluation of the Storage Stability of Extracellular Vesicles
11:31

Evaluation of the Storage Stability of Extracellular Vesicles

Published on: May 22, 2019

14.0K

Related Experiment Videos

Last Updated: May 21, 2025

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
08:02

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells

Published on: September 23, 2021

2.5K
A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

10.1K
Evaluation of the Storage Stability of Extracellular Vesicles
11:31

Evaluation of the Storage Stability of Extracellular Vesicles

Published on: May 22, 2019

14.0K

Area of Science:

  • Oncology
  • Cell Biology
  • Immunology

Background:

  • Breast cancer (BC) presents significant heterogeneity and treatment challenges.
  • Extracellular vesicles (EVs) mediate intercellular communication via transported bioactive molecules.
  • Tumor-derived EVs are key regulators of the tumor microenvironment (TME) and BC progression.

Purpose of the Study:

  • To review the multifaceted roles of BC tumor-derived EVs in the TME.
  • To explore how EVs influence immune modulation, angiogenesis, and metastasis.
  • To highlight therapeutic strategies targeting EV-mediated pathways.

Main Methods:

  • Literature review of studies on breast cancer extracellular vesicles.
  • Analysis of EV cargo and their impact on cellular processes.
  • Examination of EV roles in immune evasion and drug resistance.

Main Results:

  • Tumor-derived EVs modulate immune cells (macrophages, dendritic cells, T cells), promoting immune evasion.
  • EVs contribute to angiogenesis and metastasis in breast cancer.
  • Tumor-derived EVs are implicated in mediating therapeutic drug resistance.

Conclusions:

  • Understanding BC tumor-derived EVs is crucial for developing novel therapeutic strategies.
  • Targeting EV-mediated pathways offers promise for enhancing cancer treatment efficacy.
  • EVs represent potential biomarkers and therapeutic targets for improved patient outcomes.