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Updated: May 21, 2025

Comet Assay as an Indirect Measure of Systemic Oxidative Stress
Published on: May 22, 2015
Relationship between cognitive impairment and oxidative stress markers in patients with early-onset schizophrenia
Rongli An1, Xianli Zhang2, Xianglei Luo3
1Rongli An, Department of Psychiatry, The Eighth Hospital of Shijiazhuang, Shijiangzhuang 050080, Hebei, P.R. China.
Objective:
To investigate the relationship between cognitive impairment and oxidative stress markers in patients with early-onset schizophrenia(EOS).
Methods:
This was a retrospective study. A total of 42 patients with EOS admitted to The Eighth Hospital of Shijiazhuang from December 2021 to December 2023 and 42 healthy volunteers were included in this study and classified as the observation group and the control group. Cognitive impairment and oxidative stress markers were assessed in both groups. The Measurement and Treatment Research to Improve Cognition in Schizophrenia(MATRICS) Consensus Cognitive Battery(MCCB) was used to evaluate cognitive function, and the serum levels of superoxide dismutase(SOD), malondialdehyde, glutathione peroxidase(GSH-Px), catalase, homocysteine, and nitric oxide(NO) were measured. Pearson correlation analysis was conducted to clarity the relationship between cognitive function and oxidative stress markers.
Results:
The SOD and GSH-Px levels in the observation group were lower than in the control group, while homocysteine, catalase, malondialdehyde, and NO levels were higher in the observation group. Compared to the control group, patients in the observation group scored significantly lower for information processing speed, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition (P< 0.01, respectively). SOD and malondialdehyde levels were found to have a significant negative correlation with information processing speed, with r values of -0.342 and -0.350, respectively (P < 0.05).
Conclusion:
Cognitive impairment in patients with EOS appears to be associated with oxidative stress. There is a significant negative correlation between the levels of SOD and malondialdehyde and information processing speed.
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