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Large-for-size syndrome prophylaxis in infant liver recipients with low body mass

Konstantin Semash1, Timur Dzhanbekov2

  • 1Department of Mini-Invasive Surgery, National Children's Medical Center, Tashkent 100171, Toshkent, Uzbekistan. doctorsemash@gmail.com.

World Journal of Transplantation
|March 19, 2025
PubMed

Insights

Pediatric liver transplantation using the left lateral section (LLS) is common for liver disease. Matching adult donor graft size to a child

Area of Science:

  • Hepatology
  • Pediatric Surgery
  • Transplantation Medicine

Background:

  • Left lateral section (LLS) liver transplantation is a standard treatment for pediatric liver diseases.
  • Significant challenges exist in matching adult donor graft size to pediatric recipients.
  • LLs grafts are particularly relevant for infant liver transplantation.

Purpose of the Study:

  • To review the evolution of left lateral section (LLS) liver transplantation in children.
  • To discuss methods for determining adequate functional liver mass in pediatric recipients.
  • To explore strategies for managing complications related to large-for-size grafts in infants.

Main Methods:

  • Literature review of historical developments in pediatric liver transplantation.
  • Analysis of techniques for calculating functional liver mass.
  • Examination of strategies to mitigate complications from oversized grafts.

Main Results:

  • LLS transplantation is a viable option for pediatric liver disease.
  • Accurate assessment of functional liver mass is crucial for successful outcomes.
  • Specific techniques can help manage complications associated with large grafts in infants.

Conclusions:

  • Left lateral section (LLS) liver transplantation is a critical tool in pediatric hepatology.
  • Addressing size discrepancies and potential complications is key to successful infant liver transplantation.
  • Continued research into graft sizing and complication management will improve outcomes.

Keywords:
Abdominal wall reconstructionLarge-for-size syndromeLeft lateral sector graftLiver resectionLiver transplantationLiver volumetryMonosegmental transplantationPediatric liver transplantationPreoperative evaluation of donor and recipientReduced size liver graft

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