Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Non-destructive Tests for Concrete Strength01:12

Non-destructive Tests for Concrete Strength

572
The rebound hammer test, also known as the Schmidt hammer test, is a non-destructive technique for evaluating the hardness of concrete and, indirectly, the strength of concrete. It operates on the principle that the rebound of a spring-driven mass from a concrete surface correlates to the surface's hardness. The device comprises a mass within a tubular housing, a spring mechanism, and a plunger that strikes the concrete. Upon release, the energy imparted to the mass by the spring causes it...
572
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

916
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
916
Induced-fit Model01:13

Induced-fit Model

89.5K
Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
89.5K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.1K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.1K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.6K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.6K
Induced Electric Dipoles01:28

Induced Electric Dipoles

4.8K
A permanent electric dipole orients itself along an external electric field. This rotation can be quantified by defining the potential energy because the external torque does work in rotating it. Then, the potential energy is minimum at the parallel configuration and maximum at the antiparallel configuration. While the former is a stable equilibrium, the latter is an unstable equilibrium.
Since the absolute value of potential energy holds no physical meaning, its zero value can be chosen as per...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>CSN1S1</i> and <i>CSN3</i> genetic variants affect milk quality traits in the buffalo population in Serbia.

Journal of animal science and technology·2026
Same author

Association Between Multiple Sclerosis Severity and Functional Variants in Key Antioxidant Defense and Ferroptosis-Related Genes.

Biology·2026
Same author

Extrapyramidal and anticholinergic reactions in an adolescent patient: a case for pharmacogenetic consideration.

Biochemia medica·2026
Same author

Stroke-point-of-care ultrasound: a new holistic approach to bedside evaluation in stroke patients using ultrasound.

European stroke journal·2026
Same author

Circulating EV miRNA Cargo in Glioblastoma Patients Is Associated with Distinct Gene Expression Signatures in Peripheral Immune Cells, Suggesting an Early, Compartment-Specific Immune Priming State.

Biomedicines·2026
Same author

Clinical Significance of Microembolic Signal Detection in Acute Ischemic Stroke: Insights Into Ongoing Cerebral Embolization and Occult Etiologies.

European journal of neurology·2026

Related Experiment Video

Updated: Feb 10, 2026

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats
09:43

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats

Published on: October 5, 2021

3.0K

COCAINE-INDUCED MIDLINE DESTRUCTIVE LESIONS.

Hanna Pašić1, Branka Vidrih1,2, Iva Šarac3

  • 1Department of Psychiatry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

Acta Clinica Croatica
|March 19, 2025
PubMed
Summary

Cocaine-induced midline destructive lesions (CIMDL) are a rare autoimmune condition affecting predisposed patients. Diagnosis involves clinical evaluation, imaging, and serology, with pANCA positivity potentially influencing disease presentation.

Keywords:
Anti-neutrophil cytoplasmic antibodiesCocaineCocaine-induced midline destructive lesions

More Related Videos

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

18.0K
A Procedure for Studying the Footshock-Induced Reinstatement of Cocaine Seeking in Laboratory Rats
08:54

A Procedure for Studying the Footshock-Induced Reinstatement of Cocaine Seeking in Laboratory Rats

Published on: January 6, 2011

21.7K

Related Experiment Videos

Last Updated: Feb 10, 2026

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats
09:43

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats

Published on: October 5, 2021

3.0K
Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

18.0K
A Procedure for Studying the Footshock-Induced Reinstatement of Cocaine Seeking in Laboratory Rats
08:54

A Procedure for Studying the Footshock-Induced Reinstatement of Cocaine Seeking in Laboratory Rats

Published on: January 6, 2011

21.7K

Area of Science:

  • Immunology
  • Otolaryngology
  • Neurology

Background:

  • Prolonged cocaine inhalation can lead to severe nasal and sinus destruction.
  • Cocaine-induced midline destructive lesions (CIMDL) represent a rare autoimmune inflammatory process.
  • These lesions are associated with atypical antineutrophil cytoplasmic antibodies (ANCA).

Observation:

  • Patients typically present with epistaxis, nasal obstruction, hyposmia, sinus infections, and facial pain.
  • A case presented with brain extension mimicking an ischemic-like lesion with edema.
  • Diagnosis relies on medical history, clinical examination, imaging (MRI), and laboratory tests.

Findings:

  • CIMDL are characterized by an autoimmune necrotizing inflammatory phenomenon.
  • Atypical ANCA, particularly pANCA positivity, is linked to CIMDL.
  • The case highlighted the potential for CIMDL to manifest with neurological complications.

Implications:

  • Early diagnosis and recognition of CIMDL are crucial for appropriate management.
  • Understanding the autoimmune basis of CIMDL can guide treatment strategies.
  • Further research into the role of ANCA in CIMDL pathogenesis is warranted.