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Remnant cholesterol and suicide attempts in untreated first-episode major depressive disorder

  • 0Department of Psychiatry, Nanjing Lishui District Psychiatric Hospital, Lishui, China.
Frontiers in Psychiatry +

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March 19, 2025

|

March 19, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Remnant cholesterol (RC) levels show a non-linear link to suicide attempts (SA) in Chinese patients with first-episode major depressive disorder (MDD). A significant positive correlation exists when RC is below 1.99 mmol/L.

Area Of Science

  • Cardiovascular Health
  • Psychiatry
  • Biomarkers in Mental Health

Background

  • Major depressive disorder (MDD) is a leading cause of disability worldwide.
  • Suicide attempts (SA) are a critical concern in MDD patients.
  • Lipid metabolism, including remnant cholesterol (RC), is increasingly recognized for its potential role in psychiatric conditions.

Purpose Of The Study

  • To investigate the relationship between remnant cholesterol (RC) levels and suicide attempts (SA).
  • To examine this association in Chinese patients diagnosed with untreated first-episode major depressive disorder (UFE MDD).

Main Methods

  • A cohort of 1718 patients with UFE MDD was analyzed.
  • Demographic, clinical, and blood lipid data were collected.
  • Multivariable logistic regression and two-piecewise linear regression models assessed the RC-SA association, controlling for confounders.

Main Results

  • A non-linear association was found between RC and SA.
  • A significant positive correlation between RC and SA was observed when RC levels were below 1.99 mmol/L.
  • No significant correlation was found when RC levels exceeded 1.99 mmol/L.

Conclusions

  • Remnant cholesterol levels exhibit a non-linear association with suicide attempts in UFE MDD patients.
  • Elevated RC below a specific threshold (1.99 mmol/L) may indicate an increased risk for SA.
  • Further research is warranted to elucidate the mechanisms underlying this relationship.

Keywords:

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