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Embolization and vessel wall perforation in argon laser recanalization
Lasers in Surgery and Medicine
|January 1, 1985
Summary
Argon laser recanalization shows no evidence of distal embolization or vessel perforation in animal and human arteries. Careful technique minimizes perforation risks, making distal embolization an unlikely concern for laser angioplasty.
Area of Science:
- Cardiovascular Medicine
- Medical Devices
- Interventional Cardiology
Background:
- Laser angioplasty development faces challenges like vessel perforation and distal embolization.
- Ensuring safety is paramount for intravascular laser catheter applications.
Purpose of the Study:
- To evaluate the risks of distal embolization and vessel wall perforation during argon laser recanalization.
- To assess the safety profile of laser angioplasty in preclinical and human arterial models.
Main Methods:
- Technetium 99-labeled thrombi were used in rabbit aortas and a human coronary artery to detect embolization.
- Argon laser recanalization was performed on thrombosed rabbit aortas, a human inferior vena cava, and human peripheral arteries with atherosclerotic plaque.
Main Results:
- No distal embolization was observed after argon laser recanalization in any tested model.
- Vessel wall perforation did not occur in thrombosed aortas, vena cava, or peripheral arteries treated with laser.
- Perforation risk can be reduced through careful laser catheter manipulation and coaxial alignment.
Conclusions:
- Distal embolization is not a significant risk associated with argon laser recanalization.
- Argon laser angioplasty demonstrates a favorable safety profile regarding vessel perforation when appropriate techniques are employed.