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Updated: Aug 9, 2026

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications
Published on: May 17, 2022
Recent advances in bioactive hydrogel microspheres: Material engineering strategies and biomedical prospects
Junjiang Yue1, Zhengbiao Liu2, Lu Wang2
1Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China.
Abstract:
Hydrogel microspheres are a class of hydrophilic polymeric particles in microscale, which has been developed as a new type of functional biomaterials for wide-range biomedical applications in recent years. This review provides a comprehensive overview of the preparation methods for hydrogel microspheres, including droplet microfluidics, electrospray and emulsion was first summarized. At the same time, we analyze the impacts of these methods on the properties of hydrogel microspheres and explore various functionalization strategies for enhancing their bioactivity and expanding their biomedical applications. In addition, we discuss the recent advances and the further prospect of hydrogel microspheres in life science applications, particularly in cell biology research, bioanalysis and detection, as well as tissue repair and regeneration. By synthesizing the latest developments, this review aims to offer valuable insights and strategies for optimizing hydrogel microspheres in diverse application scenarios and inspire future research and practical innovations.
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