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Construction and validation of a cell death-related genes prognosis signature of hepatocellular carcinoma

  • 0Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Beihua University, Jilin, China.
Translational Cancer Research +

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March 19, 2025

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March 19, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

A new prognostic model integrating cell death-related genes (CDGRs) predicts survival in hepatocellular carcinoma (HCC). High-risk HCC patients show poorer outcomes and altered immune microenvironments, suggesting CDGRs as potential therapeutic biomarkers.

Area Of Science

  • Oncology
  • Molecular Biology
  • Immunology

Background

  • Cell death pathways (apoptosis, autophagy, necroptosis) are crucial in hepatocellular carcinoma (HCC) progression and patient outcomes.
  • Integrating these pathways into a prognostic signature for HCC has not been previously reported.

Purpose Of The Study

  • To investigate the association between cell death-related genes (CDGRs) and prognosis in HCC.
  • To explore the relationship between CDGRs, the tumor immune microenvironment, and immune checkpoints in HCC.

Main Methods

  • Utilized RNA expression profiles and clinical data from TCGA, GEO, and ICGC databases for HCC.
  • Identified prognostic genes via univariate Cox regression and developed a risk score using Lasso Cox regression.
  • Analyzed correlations between risk score, clinicopathological features, immune cell infiltration, and immune checkpoint expression.

Main Results

  • A prognostic risk model based on CDGRs was constructed, effectively subgrouping HCC patients.
  • High-risk patients demonstrated significantly lower overall survival (OS) rates compared to low-risk patients.
  • The high-risk group exhibited reduced immune cell infiltration and elevated immune checkpoint molecule expression, with the risk score showing predictive ability via ROC curve analysis.

Conclusions

  • The developed cell death-related gene signature serves as a valuable predictive tool for HCC survival.
  • This signature shows potential as a therapeutic biomarker for hepatocellular carcinoma.

Keywords: