Diet, oxidative stress and MAFLD: a mini review

Area of Science:

• Hepatology
• Nutritional Science
• Oxidative Stress Research

Background:

• Metabolic dysfunction-associated fatty liver disease (MAFLD), also known as non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD), is a prevalent global chronic liver condition.
• MAFLD progression is characterized by a cycle where oxidative stress exacerbates de-novo lipogenesis and hepatic steatosis.
• Non-enzymatic antioxidants, commonly found in dietary sources, play a crucial role in mitigating oxidative stress.

Purpose of the Study:

• To review existing research on food-derived antioxidants in the context of MAFLD.
• To elucidate the oxidative stress-related regulatory network implicated in MAFLD pathogenesis.
• To propose novel avenues for MAFLD prevention and therapeutic intervention based on dietary antioxidants.

Main Methods:

• Comprehensive literature search of studies investigating food-derived antioxidants and their impact on MAFLD.
• Analysis of the mechanisms by which oxidative stress influences lipid metabolism and steatosis in MAFLD.
• Synthesis of findings to construct a regulatory network illustrating the interplay between antioxidants, oxidative stress, and MAFLD.

Main Results:

• Dietary antioxidants demonstrate potential in counteracting the oxidative stress associated with MAFLD.
• Specific food-derived compounds may modulate de-novo lipogenesis and reduce hepatic steatosis.
• An intricate network highlights the role of oxidative stress in MAFLD pathophysiology.

Conclusions:

• Food-derived antioxidants represent a promising, natural approach for managing MAFLD.
• Targeting the oxidative stress cycle through dietary interventions offers a viable strategy for MAFLD prevention and treatment.
• Further research into specific dietary antioxidants and their mechanisms is warranted for clinical application.