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Published on: May 28, 2019
Association between uric acid-albumin ratio and spontaneous reperfusion in ST-segment elevation myocardial infarction
Jing Nan1, Shuai Meng1, Ruo-Fei Jia1
1Department of Cardiology and Macrovascular Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Insights
The uric acid-albumin ratio (UAR) is a significant predictor of spontaneous reperfusion (SR) in ST-segment elevation myocardial infarction (STEMI) patients. Higher UAR levels indicate a greater likelihood of successful SR after treatment.
Area of Science:
- Cardiology
- Biomarkers
- Myocardial Infarction Research
Background:
- The uric acid-albumin ratio (UAR) has been linked to various diseases.
- The association between UAR and spontaneous reperfusion (SR) in ST-segment elevation myocardial infarction (STEMI) patients remains unexplored.
Purpose of the Study:
- To investigate the relationship between UAR and SR in STEMI patients.
- To determine if UAR can serve as a predictive marker for SR in STEMI.
Main Methods:
- Retrospective analysis of STEMI patients undergoing primary coronary angiography.
- Classification of patients into SR and non-SR groups based on angiography.
- Logistic regression and ROC curve analysis to assess UAR's predictive value for SR.
Main Results:
- STEMI patients with SR were older and had higher levels of red blood cell distribution width, C-reactive protein, and uric acid.
- Patients with SR exhibited lower platelet counts and B-type natriuretic peptide levels.
- Significantly higher UAR levels were observed in the SR group (11.1) compared to the non-SR group (8.3).
- UAR was identified as an independent risk factor for SR, with good predictive value (AUC = 0.75).
Conclusions:
- The uric acid-albumin ratio (UAR) is an independent risk factor for predicting spontaneous reperfusion (SR) in patients with ST-segment elevation myocardial infarction (STEMI).
- UAR demonstrates significant potential as a biomarker for assessing reperfusion success in STEMI.
Background:
The association between uric acid-albumin ratio (UAR) with different diseases has been evaluated before. However, the association between UAR with spontaneous reperfusion (SR) in patients with ST-segment elevation myocardial infarction (STEMI) has not been explored.
Methods:
STEMI patients admitted to our department and underwent primary coronary angiography between 1st November 2018 and 31st December 2020 were retrospectively enrolled. The patients were divided into the SR group and the non-SR group according to the index coronary angiography results. The association between UAR and SR was evaluated by uni-variable and multi-variable logistic analysis. Receiver operating characteristic curve analysis was used to determine the optimum cut-off level of UAR in predicting SR.
Results:
Three hundred and fifty-seven patients were finally enrolled in our study, 55 patients were divided into the SR group and 302 patients were divided into the non-SR group. In uni-variable analysis, patients with SR were older (P = 0.032), with higher red blood cell distribution width (P < 0.001) and red blood cell distribution width-to-platelet ratio (P < 0.001), higher level of C-reactive protein (P = 0.046), higher level of uric acid (P < 0.001) compared with patients without SR. Patients with SR had a lower level of platelets (P = 0.008), lower level of on-admission B-type natriuretic peptide (P < 0.001). As for the level of UAR, STEMI patients with SR had significantly higher levels of UAR compared with STEMI patients without SR [11.1 (8.9-13.4) vs. 8.3 (6.6-10.0), P < 0.001]. Further multi-variable logistic analysis reveals that UAR was the independent risk factor of SR in different models after adjusting different variables. Receiver operating characteristic analysis showed that UAR had good predictive value in SR (AUC = 0.75, 95% CI: 0.702-0.794, P < 0.01).
Conclusions:
Our study shows that UAR is an independent risk factor for predicting SR in STEMI patients.
