Related Experiment Video
Updated: Jul 13, 2026

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
Published on: October 12, 2016
Creating Perforations in the Sclerotic Region of the Proximal Tibia During Total Knee Arthroplasty to Enhance
Chao Sun1, Chunyan Wang2, Jintang Li1
1Department of Orthopaedic Surgery, Orthopaedic Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Objective:
In patients with varus deformity of the knee, the redistribution of the subchondral bone mineral density (BMD) of the tibia leads to sclerotic zones that may cause osteoarthritis. Drilling the sclerotic area of the tibia prior to cementing during total knee arthroplasty is advisable practice. However, the extent of the sclerotic area and the effect of drilling on the tibial component are not well defined. We aimed to quantify the BMD and sclerotic bone distribution of the knee to clarify the effect of drilling on the stability of the prosthesis.
Methods:
Our retrospective cohort study enrolled a total of 97 patients from December 2018 to December 2019, categorized into drilled and nondrilled groups, with their computed tomography (CT) knee joint images documented. The proximal tibia image was divided into nine regions, the BMD of each region calculated, and CT values compared between the affected and normal sides. We established finite element models to analyze the drilling and stress distribution. The differences in CT values were assessed using the paired t test and Wilcoxon signed-rank test.
Results:
The mean thickness of sclerotic bone was 7.7 ± 1.4 mm, and the surface area was 441.9 ± 89.4 mm2. The CT values of the affected anteromedial, anterolateral, mediomedial, mediolateral, posteromedial, posteromedian, and posterolateral tibial areas were significantly higher than their normal counterparts. Stress concentration around the boreholes in all finite element models is minimal, with stress values ranging from 0.01 to 3.73 MPa, markedly lower than the 13.93 MPa observed in the undrilled model.
Conclusion:
Abnormal stress in the proximal tibia alters the distribution pattern of BMD, and drilling in the sclerotic area is associated with improved prosthesis stability.
Related Concept Videos
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Ankle Joint

