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  11. Pathology Of Clostridium Colinum Infection In Quail

Pathology of Clostridium colinum infection in quail

Agustín Rebollada-Merino1, Jey W Koehler2, Martí Pumarola3

  • 1Cornell University, Ithaca, NY.

Veterinary Pathology
|March 19, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Clostridium colinum causes quail disease, leading to ulcerative enteritis. This study highlights key diagnostic features including gross and microscopic lesions, and PCR detection for accurate diagnosis in affected birds.

Area of Science:

  • Avian pathology
  • Bacterial infectious diseases
  • Veterinary diagnostics

Background:

  • Clostridium colinum infection, known as quail disease, causes ulcerative enteritis in avian species.
  • The pathogenesis of C. colinum infection remains poorly understood.
  • Accurate diagnostic methods are crucial for managing outbreaks in quail populations.

Purpose of the Study:

  • To retrospectively analyze cases of C. colinum infection in quail.
  • To identify key pathological findings and diagnostic markers for C. colinum enteritis.
  • To correlate clinical signs, gross lesions, and histopathological findings with PCR results.

Main Methods:

  • Retrospective review of necropsy reports from quail submitted between 1992-2022.
  • Polymerase chain reaction (PCR) using 16S rRNA gene for C. colinum detection in formalin-fixed, paraffin-embedded tissues.
Keywords:
Clostridium colinumcentral nervous systementeritishepatitis

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  • Analysis of gross and microscopic lesions, clinical history, and diagnostic findings.

    • Main Results:

    • C. colinum was detected by PCR in 96% of cases; isolation rate was 17%.
    • Bobwhite quail, particularly juveniles, were most affected, presenting with high mortality, lethargy, diarrhea, and pectoral muscle atrophy.
    • Consistent findings included transmural ulcerative enteritis (jejunum most affected), hepatic necrosis (63%), and neuronal changes (63%).

    Conclusions:

    • Diagnosis of C. colinum infection should integrate gross and microscopic pathological findings with PCR confirmation.
    • The study provides a comprehensive overview of the disease's presentation and diagnostic indicators in quail.
    • Understanding these features aids in timely and accurate diagnosis, crucial for disease control.
    lesions
    quail disease