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Multicentric Reticulohistiocytosis-Histopathologic Spectrum in Indian Patients.

Lavanya Murugesu¹, Rajalakshmi Tirumalae²

¹Department of Pathology, Sri Venkateshwaraa Medical College Hospital and Research Centre, Puducherry, India ; and.

The American Journal of Dermatopathology

|March 19, 2025

Summary

Multicentric reticulohistiocytosis (MRH) is a rare condition causing joint pain and skin lesions. Careful clinicopathologic correlation is crucial for diagnosis, as histiocyte appearance alone may not be definitive.

Keywords:

arthritis multicentric reticulohistiocytosis oncocytoid histiocytes

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Area of Science:

Dermatopathology
Rheumatology
Oncology

Background:

Multicentric reticulohistiocytosis (MRH) is a rare histiocytic disorder.
Characterized by polyarthritis and papulonodular lesions affecting skin, mucosa, and organs.
Strongly associated with autoimmune diseases and malignancies.

Purpose of the Study:

To analyze the histopathological features of Multicentric reticulohistiocytosis (MRH).
To highlight the importance of clinicopathologic correlation in diagnosing MRH.

Main Methods:

Retrospective analysis of 4 Multicentric reticulohistiocytosis (MRH) cases from 2012-2023.
Review of histopathological findings from biopsies.
Correlation with clinical data, including associated conditions and follow-up.

Main Results:

The study included 4 patients with a mean age of 48 years and no gender predilection.
All patients presented with papulonodular skin lesions.
Two cases were associated with arthritis, and two with malignancy; diagnosis was sometimes delayed until malignancy was identified.

Conclusions:

Histopathological diagnosis of MRH requires careful clinicopathologic correlation.
Histiocyte morphology in MRH can be variable and may not be diagnostic on its own.
Delayed diagnosis is possible, especially when malignancy is a concurrent or subsequent finding.