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Updated: May 21, 2025

Light-Controlled Fermentations for Microbial Chemical and Protein Production

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Published on: March 22, 2022

Control of a Gel-Forming Chemical Reaction Network Using Light-Triggered Proton Pumps.

Jacqueline Figueiredo da Silva^1,2, Ardeshir Roshanasan², Marcel Bus²

¹IBM Research Europe - Zurich, Säumerstrasse 4, 8803 Rüschlikon, Switzerland.

Langmuir : the ACS Journal of Surfaces and Colloids

|March 19, 2025

Summary

This summary is machine-generated.

Researchers developed a multisensor using bacteriorhodopsin to control pH and promote fibrous growth in hydrogels. This light-driven system mimics natural processes for responsive material engineering.

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Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

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Published on: October 4, 2024

Area of Science:

Biomaterials Engineering
Biophysics
Synthetic Biology

Background:

Natural metabolic processes are influenced by environmental cues like light and pH.
Bacteriorhodopsin, a light-driven proton pump found in purple membranes, offers potential for bio-integrated sensing and actuation.
Supramolecular hydrogels exhibit pH-responsive properties, enabling dynamic structural changes.

Purpose of the Study:

To develop a novel multisensor apparatus integrating purple membrane patches with bacteriorhodopsin onto a surface.
To investigate the interaction between the bacteriorhodopsin-based system and a pH-responsive supramolecular hydrogel for fibrous matrix growth.
To evaluate the real-time morphogenesis and structural adaptations of the hydrogel in response to photostimulation.

Main Methods:

Integration of submicrometer purple membrane patches containing bacteriorhodopsin onto a surface.
Photostimulation of the integrated system to induce localized pH changes.
Monitoring of hydrogel fibrogenesis and morphogenesis using liquid atomic force microscopy and confocal laser scanning microscopy.

Main Results:

Initial photostimulation led to localized pH reductions at the membrane surface.
These pH changes catalyzed fibrogenesis within the supramolecular hydrogel.
The system successfully modulated microscale pH environments, directing targeted fibrous development in the hydrogel matrix.

Conclusions:

The developed multisensor apparatus effectively controls microscale pH environments using light-activated bacteriorhodopsin.
This system demonstrates the potential for engineering responsive biomaterials that mimic natural bioprocesses.
Real-time monitoring techniques provide valuable insights into hydrogel morphogenesis and material-environment interactions.