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Related Experiment Video

Updated: May 21, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

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Published on: March 15, 2024

DDR1 Targeting HOXA6 Facilitates Bladder Cancer Progression via Inhibiting Ferroptosis.

Xin Xie¹, Hongchao He¹, Ning Zhang¹

¹Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Journal of Cellular and Molecular Medicine

|March 19, 2025

Summary

Discoidin domain receptor 1 (DDR1) promotes bladder cancer (BC) by inhibiting ferroptosis, a cell death process. Targeting DDR1 may offer a new therapeutic strategy for BC treatment.

Keywords:

DDR1 HOXA6 bladder cancer ferroptosis progression

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Published on: October 30, 2013

Area of Science:

Oncology
Cell Biology
Molecular Mechanisms

Background:

Ferroptosis plays a critical role in bladder cancer (BC) progression.
Discoidin domain receptor 1 (DDR1) is known to promote BC progression.
The precise mechanisms by which ferroptosis is regulated in BC remain largely unexplored.

Purpose of the Study:

To investigate the regulatory role of discoidin domain receptor 1 (DDR1) in bladder cancer (BC) cell ferroptosis.
To elucidate the molecular pathways through which DDR1 influences BC ferroptosis.

Main Methods:

Screening of ferroptosis-sensitive and -resistant BC cell lines.
Quantitative PCR and Western blotting to assess DDR1 expression.
In vitro and in vivo assays to analyze DDR1's mechanism in BC ferroptosis.

Main Results:

DDR1 knockdown inhibited BC cell death induced by ferroptosis.
DDR1 modulated levels of glutathione, glutathione peroxidase 4, solute carrier family 7 member 11, malondialdehyde, Fe2+, and acyl-CoA synthetase long-chain family member 4.
DDR1's effects on ferroptosis were dependent on homeobox A6 (HOXA6).

Conclusions:

DDR1 promotes bladder cancer progression by inhibiting ferroptosis via targeting HOXA6.
DDR1 represents a potential therapeutic target for bladder cancer.