Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Development of Novel mRNA Classifiers to Stratify Preoperative Thyroid Tumor Risk.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same author

Orticochea Flap for Reconstruction of Large Scalp Defects: Outcomes and Technique.

The Laryngoscope·2026
Same author

Clinical Characteristics and Survival in Adenoid Cystic Carcinoma of Salivary and Nonsalivary Sites.

The Laryngoscope·2026
Same author

High-avidity TCR signaling induces a distinct KLR-positive exhaustion state in human tumor-infiltrating CD8 T cells associated with immunotherapy response.

bioRxiv : the preprint server for biology·2026
Same author

Amivantamab in Recurrent/Metastatic Head and Neck Squamous Cell Cancer After Checkpoint Inhibitor and Chemotherapy: Pivotal Results From the Phase Ib/II OrigAMI-4 Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

Clinical behavior and predictors of survival in major salivary gland secretory carcinoma.

Oral oncology·2026

Related Experiment Video

Updated: May 21, 2025

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

698

Long-Term Outcomes After Elective Contralateral Neck Dissection for HPV-Related Oropharyngeal Cancer.

Ray Y Wang1, Molly E Heft Neal2, Wade L Thorstad3,4

  • 1Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|March 19, 2025
PubMed
Summary

Elective contralateral neck dissection for HPV-related oropharyngeal cancer offers excellent regional control with minimal functional impact. Most patients can avoid radiation, reducing long-term toxicity and maintaining oncologic outcomes.

Keywords:
elective neck dissectionhead and neck canceroropharyngeal cancerpatient‐reported outcomesradiation

More Related Videos

Surgical Treatment of an Endolymphatic Sac Tumor
04:34

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

562
Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
06:57

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

10.3K

Related Experiment Videos

Last Updated: May 21, 2025

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

698
Surgical Treatment of an Endolymphatic Sac Tumor
04:34

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

562
Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
06:57

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

10.3K

Area of Science:

  • Otolaryngology
  • Head and Neck Surgery
  • Oncology

Background:

  • Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) often presents with occult nodal disease in the contralateral neck.
  • Elective treatment reduces the risk of contralateral neck failure, but optimal strategies balancing toxicity and control are needed.

Purpose of the Study:

  • To evaluate the efficacy and functional outcomes of elective contralateral neck dissection in patients with HPV-related OPSCC.
  • To determine if contralateral neck radiation can be avoided in select cases without compromising oncologic control.

Main Methods:

  • Cross-sectional study of 64 patients with HPV-related OPSCC undergoing elective contralateral neck dissection (2002-2018).
  • Assessment of long-term patient-reported functional outcomes and oncologic surveillance.
  • Analysis of occult nodal metastasis rates and subsequent treatment decisions.

Main Results:

  • 19% of patients had occult nodal metastasis in the contralateral neck; 9 received adjuvant radiation.
  • No regional recurrences occurred in the contralateral neck following dissection.
  • Five-year progression-free survival was 82.0% and locoregional control was 93.0% with minimal functional impairment (Neck-Dissection Impairment Index mean 94.4).

Conclusions:

  • Elective contralateral neck dissection provides excellent regional control for HPV-related OPSCC.
  • Most patients can avoid contralateral neck radiation, decreasing toxicity without compromising oncologic outcomes.
  • This approach minimizes long-term functional impairment and treatment-related side effects.