Jove
Visualize
Contact Us

Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

1.1K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
1.1K
Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

1.5K
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sliding into Place: The Lymphatic Vessel Endothelial Hyaluronan Receptor LYVE-1 and Its Role as a Mediator of Cell Entry and Trafficking in the Lymphatics.

Biomolecules·2026
Same author

Cardiac lymphatics retain LYVE-1-dependent macrophages during neonatal mouse heart regeneration.

Nature cardiovascular research·2025
Same author

Structure and unusual binding mechanism of the hyaluronan receptor LYVE-1 mediating leucocyte entry to lymphatics.

Nature communications·2025
Same author

Lymphatic trafficking of immune cells and insights for cancer metastasis.

Clinical & experimental metastasis·2023
Same author

Lymphatic Clearance of Immune Cells in Cardiovascular Disease.

Cells·2021
Same author

Hyaluronan and Its Receptors: Key Mediators of Immune Cell Entry and Trafficking in the Lymphatic System.

Cells·2021
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 21, 2025

Non-surgical Intratracheal Instillation of Mice with Analysis of Lungs and Lung Draining Lymph Nodes by Flow Cytometry
08:01

Non-surgical Intratracheal Instillation of Mice with Analysis of Lungs and Lung Draining Lymph Nodes by Flow Cytometry

Published on: May 2, 2011

57.5K

An in-depth look at lung lymphatics.

David G Jackson1

  • 1University of Oxford, MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine , Oxford, UK.

The Journal of Experimental Medicine
|March 19, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel 3D-printed window for intravital imaging, allowing visualization of lung lymphatic function and immune cell trafficking in real-time within mechanically ventilated mice.

More Related Videos

Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches
06:31

Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches

Published on: June 25, 2020

3.9K
Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs
10:00

Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs

Published on: January 3, 2025

2.8K

Related Experiment Videos

Last Updated: May 21, 2025

Non-surgical Intratracheal Instillation of Mice with Analysis of Lungs and Lung Draining Lymph Nodes by Flow Cytometry
08:01

Non-surgical Intratracheal Instillation of Mice with Analysis of Lungs and Lung Draining Lymph Nodes by Flow Cytometry

Published on: May 2, 2011

57.5K
Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches
06:31

Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches

Published on: June 25, 2020

3.9K
Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs
10:00

Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs

Published on: January 3, 2025

2.8K

Area of Science:

  • Immunology
  • Physiology
  • Medical Imaging

Background:

  • Understanding immune cell trafficking in the lungs is crucial for diagnosing and treating respiratory diseases.
  • Current imaging techniques have limitations in visualizing dynamic lymphatic processes in vivo.
  • Mechanically ventilated conditions present unique challenges for studying lung immune responses.

Purpose of the Study:

  • To introduce a novel intravital imaging technique for visualizing lung lymphatics.
  • To observe immune cell trafficking within lung lymphatics in real-time.
  • To investigate the role of lung lymphatics in immune responses during mechanical ventilation.

Main Methods:

  • Development and application of a 3D-printed window device for intravital lung imaging.
  • Utilizing advanced microscopy to capture dynamic cellular events.
  • Employing mechanical ventilation models in mice.

Main Results:

  • The 3D-printed window enabled unprecedented visualization of lung lymphatic vessels.
  • Direct observation of immune cell migration through lung lymphatics was achieved.
  • The technique revealed the dynamic participation of lymphatics in immune cell trafficking events.

Conclusions:

  • This new imaging approach provides a powerful tool for studying lung lymphatic physiology.
  • It offers novel insights into immune cell behavior within the lung microenvironment.
  • The findings pave the way for understanding immune responses in mechanically ventilated patients.