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Non-invasive Assessment of Microvascular and Endothelial Function
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The Cardio-Ankle Vascular Index Predicts Long-Term Kidney Prognosis in Nondiabetic CKD Patients Who Underwent Kidney
Akihiro Shimizu1, Hideo Okonogi1,2, Tetsuya Kawamura1
1Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Kidney360
|March 19, 2025
Insights
The cardio-ankle vascular index (CAVI) can predict long-term kidney disease progression in patients with non-diabetic chronic kidney disease. Higher CAVI levels indicate a greater risk of declining kidney function.
Area of Science:
- Nephrology
- Cardiology
- Vascular Biology
Background:
- Arterial stiffness, measured by the cardio-ankle vascular index (CAVI), is a predictor of cardiovascular events.
- The association between CAVI and kidney prognosis, particularly in non-diabetic chronic kidney disease (CKD) patients, remains under-investigated.
- Kidney biopsy provides a unique opportunity to assess kidney health and its correlation with systemic vascular parameters.
Purpose of the Study:
- To investigate the association between CAVI and long-term kidney prognosis.
- To determine if CAVI is an independent predictor of kidney function decline in non-diabetic CKD patients.
- To establish a potential cutoff value for CAVI to identify patients at higher risk.
Main Methods:
- A longitudinal, observational study involving 46 patients with non-diabetic CKD (stages 1-4) who underwent kidney biopsy.
- CAVI was measured at the time of kidney biopsy, with a minimum follow-up of 1 year.
- The primary outcome was a 30% decline in estimated glomerular filtration rate (eGFR) or progression to end-stage kidney disease.
Main Results:
- Higher CAVI was significantly associated with the primary outcome (30% eGFR decline or end-stage kidney disease).
- Multivariate analyses confirmed CAVI as an independent predictor of poor kidney prognosis.
- A CAVI cutoff of 7.7 demonstrated high sensitivity (78%) and specificity (79%) for predicting adverse kidney outcomes.
Conclusions:
- CAVI measured at kidney biopsy is an independent predictor of long-term kidney prognosis in non-diabetic CKD patients.
- Elevated CAVI levels may indicate increased risk for kidney function deterioration.
- These findings highlight the potential of CAVI as a noninvasive tool for risk stratification in CKD management.
Abstract
No abstract available in PubMed .
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