Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

1.9K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
1.9K
Loose Connective Tissue01:26

Loose Connective Tissue

6.8K
Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
6.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep Learning Predicts Mutations and Outcomes in Gastrointestinal Stromal Tumors from Whole-Slide Images.

Cancer research·2026
Same author

[Influence of neoadjuvant radiotherapy on postoperative complications in patients with retroperitoneal sarcoma in the STRASS study].

Chirurgie (Heidelberg, Germany)·2026
Same author

Evaluating reasoning models for therapy recommendations in gastrointestinal stromal tumors: expert and LLM-based evaluations of OpenAI o1 and DeepSeek-R1.

Journal of cancer research and clinical oncology·2026
Same author

Treatment of retroperitoneal sarcoma in Germany between 2000 and 2022: a retrospective analysis from the German Cancer Registry Group.

Journal of cancer research and clinical oncology·2026
Same author

The Health-Related Quality of Life of German Desmoid Patients: Results from the PROSa-DES and PROSa Study.

Cancers·2026
Same author

Auricular assessment for abdominal pain: A prospective double-blind pilot study on diagnostic potential of auricular somatotopy.

Journal of integrative medicine·2026
Same journal

[Timing of the closure of ileostomy after low anterior rectal resection for rectal cancer: results of a meta-analysis].

Chirurgie (Heidelberg, Germany)·2026
Same journal

[Defect coverage on the hand : A reconstructive challenge].

Chirurgie (Heidelberg, Germany)·2026
Same journal

Chirurgie (Heidelberg, Germany)·2026
Same journal

[Massive/mass-forming ductular reaction (MDR) in angioinvasive hepatocellular carcinoma : Pathogenesis and differential diagnoses of a hepatic pseudotumor].

Chirurgie (Heidelberg, Germany)·2026
Same journal

[Esophageal NEN: update on diagnostics and surgical treatment].

Chirurgie (Heidelberg, Germany)·2026
Same journal

[Working conditions in endocrine surgery : A study among participants of the 43rd annual conference of the Surgical Working Group Endocrinology].

Chirurgie (Heidelberg, Germany)·2026
See all related articles

Related Experiment Video

Updated: May 23, 2025

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

Published on: July 28, 2020

9.5K

[Localized soft tissue sarcomas].

Madelaine Hettler1, Jens Jakob2

  • 1Sektion Sarkomchirurgie, Chirurgische Klinik, Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim der Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.

Chirurgie (Heidelberg, Germany)
|March 19, 2025
PubMed
Summary
This summary is machine-generated.

Soft tissue sarcomas are rare cancers from mesenchymal tissue, with over 80 subtypes. Diagnosis involves imaging, biopsy, and sarcoma boards for effective treatment planning and patient follow-up.

Keywords:
BiopsyComplete resectionFNCLCC gradingSarcomaSarcoma center

More Related Videos

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

14.2K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

1.2K

Related Experiment Videos

Last Updated: May 23, 2025

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

Published on: July 28, 2020

9.5K
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

14.2K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

1.2K

Area of Science:

  • Oncology
  • Surgical Pathology
  • Medical Imaging

Background:

  • Soft tissue sarcomas (STS) are rare malignant tumors originating from mesenchymal tissue.
  • They present with diverse histological subtypes, including frequent liposarcomas and leiomyosarcomas.
  • STS commonly occur in extremities, trunk, and retroperitoneal regions.

Purpose of the Study:

  • To outline the established diagnostic and treatment algorithm for soft tissue space-occupying lesions.
  • To emphasize the importance of multidisciplinary sarcoma boards in clinical practice.
  • To define the standard surgical approach and adjuvant therapies for soft tissue sarcomas.

Main Methods:

  • Multimodal diagnostic approach including imaging and biopsy for lesions >3 cm.
  • Establishment of a multidisciplinary sarcoma board for treatment strategy determination.
  • Surgical resection (R0 resection) as the standard of care.
  • (Neo)adjuvant radiotherapy and/or chemotherapy for advanced or metastatic disease.
  • Regular clinical and radiological follow-ups (3-6 months intervals).

Main Results:

  • An integrated diagnostic algorithm involving imaging, biopsy, and sarcoma board review is standard for soft tissue lesions exceeding 3 cm.
  • Wide R0 resection is the established surgical standard for sarcoma treatment.
  • Adjuvant therapies and multidisciplinary consultation are crucial for managing locally advanced or metastatic sarcomas.
  • Structured follow-up protocols are essential for monitoring treatment response and detecting recurrence.

Conclusions:

  • The current clinical practice effectively manages soft tissue sarcomas through a combination of advanced diagnostics, surgical expertise, and tailored adjuvant therapies.
  • Multidisciplinary sarcoma boards play a pivotal role in optimizing treatment strategies and improving patient outcomes.
  • Adherence to standardized follow-up schedules is critical for long-term patient management.