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Updated: May 5, 2026
Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
Evaluation of Anti-aging Agents Using the D-Galactose-Induced Accelerated Aging Model
Serdar Bora Bayraktaroğlu1,2, Raife Dilek Turan1, Neslihan Pakize Taşlı1
1Yeditepe Universitesi, Istanbul, Turkey.
Abstract:
The aging population is rapidly increasing, emphasizing the importance of understanding aging mechanisms and developing effective anti-aging therapies. This chapter investigates the efficacy of novel anti-aging agents, including exosomes and boron compounds, using the D-galactose-induced accelerated aging model. Both in vitro (skin organoid models) and in vivo (rat models) systems are employed to explore cellular, molecular, and histological changes. This comprehensive analysis provides critical insights into the potential of these agents in reversing age-associated pathologies.
Insights
Novel anti-aging agents like exosomes and boron compounds show promise in reversing aging. Studies using accelerated aging models in vitro and in vivo reveal their potential to combat age-related decline.
Area of Science:
- Gerontology and Regenerative Medicine
- Biotechnology and Nanomedicine
Background:
- The global population is aging, increasing the need for effective anti-aging strategies.
- Understanding aging mechanisms is crucial for developing interventions to improve healthspan.
Purpose of the Study:
- To investigate the efficacy of novel anti-aging agents, specifically exosomes and boron compounds.
- To evaluate these agents in a D-galactose-induced accelerated aging model.
Main Methods:
- Utilized both in vitro (skin organoid models) and in vivo (rat models) experimental systems.
- Analyzed cellular, molecular, and histological changes associated with aging and treatment.
Main Results:
- Exosomes and boron compounds demonstrated potential in mitigating age-associated pathologies.
- Observed reversal of specific aging markers at cellular and molecular levels.
Conclusions:
- Novel agents like exosomes and boron compounds hold significant therapeutic potential for aging.
- Further research into these agents could lead to effective anti-aging therapies.
