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Quantitative evaluation of left ventricular function using computed tomography.

D F Guthaner, M Nassi, B Bradley

    Medical Physics
    |May 1, 1985
    PubMed
    Summary
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    Computed tomography (CT) offers accurate noninvasive volume measurements. This study validated CT for cardiac imaging, finding good correlation for ejection fraction in animal models.

    Area of Science:

    • Medical Imaging
    • Cardiovascular Imaging
    • Biomedical Engineering

    Background:

    • Computed tomography (CT) is a noninvasive imaging technique.
    • CT allows for high-resolution cross-sectional tomographic images.
    • Volume measurements are independent of geometric configuration.

    Purpose of the Study:

    • To validate the CT method for volume determination using a phantom.
    • To estimate left ventricular volumes and ejection fraction in an animal model.
    • To compare CT results with a standard angiographic method.

    Main Methods:

    • A phantom with known volume and controllable motion was used for validation.
    • Missing angle reconstruction algorithms for gating were applied.
    • Left ventricular volumes and ejection fraction were measured in an experimental animal.

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    Main Results:

    • A good correlation (P < 0.05) was achieved during phantom validation.
    • Left ventricular volumes correlated poorly between CT and angiography.
    • Ejection fraction obtained by CT correlated well (r = 0.9) with the standard method.

    Conclusions:

    • CT is a validated method for noninvasive volume measurements.
    • CT shows promise for accurate ejection fraction assessment in animal models.
    • Challenges in border definition and partial volume effects were noted for CT-based volume measurements.