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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Overview of Hematopoiesis01:20

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Author Spotlight: Advancing In Vitro Blood Cell Production with Single-Cell Multiomics and Functional Genomics
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HemAtlas: A Multi-omics Hematopoiesis Database.

Zhixin Kang1,2,3, Tongtong Zhu4,5,3, Dong Zou4,5

  • 1State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Genomics, Proteomics & Bioinformatics
|March 19, 2025
PubMed
Summary
This summary is machine-generated.

HemAtlas maps hematopoiesis across species and conditions, aiding in understanding blood development and generating hematopoietic stem and progenitor cells (HSPCs) in vitro.

Keywords:
In vitro hematopoietic stem and progenitor cellCross-species analysisDevelopmental hematopoiesisHematopoietic databaseMulti-omics

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Area of Science:

  • Hematology
  • Systems Biology
  • Genomics

Background:

  • High-throughput omics technologies enable systematic exploration of hematopoietic organs.
  • Understanding in vivo hematopoiesis and in vitro hematopoietic stem and progenitor cell (HSPC) generation requires a cross-species developmental landscape.

Purpose of the Study:

  • To develop HemAtlas, a platform for systematic mapping of hematopoiesis in vivo and in vitro.
  • To provide a comprehensive resource for exploring multi-omics data across species and experimental models.

Main Methods:

  • Integrated multi-omics datasets from humans, mice, zebrafish, and in vitro HSPC cultures.
  • Utilized literature curation, data normalization, and uniform integration methods.
  • Developed functional modules for interactive data exploration and visualization.

Main Results:

  • Constructed organ-wide hematopoietic references with manually curated cell annotations for each species.
  • Enabled cross-stage, cross-species, and cross-model single-cell analyses.
  • Revealed HSPC stage-specific properties through a comprehensive cross-stage development map.

Conclusions:

  • HemAtlas provides a crucial resource for advancing the understanding of hematopoiesis.
  • The platform facilitates the generation of functional HSPCs in vitro.
  • HemAtlas enables comprehensive decoding of cross-stage developmental hematopoiesis at the organ level.