Microbiome Signatures and Dysbiotic Patterns in Oral Cancer and Precancerous Lesions
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View abstract on PubMed
Summary
This summary is machine-generated.The oral microbiome in precancerous lesions is similar to normal tissue, but oral squamous cell carcinoma (OSCC) shows distinct microbial changes. OSCC is linked to reduced Streptococcus and increased amino-acid-degrading bacteria.
Area Of Science
- Microbiology
- Oncology
- Oral Health
Background
- The oral microbiome's role in oral squamous cell carcinoma (OSCC) is known, but its state during precancerous stages is unclear.
- Previous research focused on comparing OSCC and normal tissue microbiomes, neglecting precancerous conditions and influencing factors.
Purpose Of The Study
- To analyze oral microbiome composition across normal, precancerous, and OSCC states.
- To identify specific bacterial changes and their potential ecological roles in OSCC development.
Main Methods
- 16S rRNA amplicon sequencing was used to analyze mucosa-associated microbiomes from 51 patients.
- Compositional and co-occurrence patterns of bacteria in normal, precancerous, and OSCC lesions were investigated.
Main Results
- The microbiome of precancerous lesions was indistinguishable from normal mucosa.
- The OSCC microbiome significantly differed, showing decreased Streptococcus and increased anaerobic bacteria like Fusobacterium and Prevotella.
- These OSCC-associated bacteria may adapt metabolically to the tumor microenvironment.
Conclusions
- Distinct oral microbiome patterns are observed across oral squamous cell carcinoma progression.
- Findings provide insights into the microbial ecology of OSCC development.
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