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Updated: Jun 18, 2026

Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay
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A roadmap to increasing access to AQP4-Ig testing for NMOSD: expert recommendations.

Raquel Vassão-Araujo1,2, Samira Apóstolos3, Angela Marie Jansen4

  • 1Santa Casa de Belo Horizonte (CAPPEM), Departamento de Neurologia, Belo Horizonte MG, Brazil.

Arquivos De Neuro-Psiquiatria
|March 19, 2025
PubMed
Summary

Neuromyelitis optica spectrum disorder (NMOSD) diagnosis in Brazil is hindered by limited access to aquaporin 4 immunoglobulin G (AQP4-IgG) testing. Improving physician knowledge and healthcare access is crucial for better patient outcomes.

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Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
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